Joystick Mapper is an application that allows you to configure your joysticks or gamepads to simulate keyboard keys/mouse movement/mouse click/mouse scroll, so you can control any app or game using them, even the ones without built-in support.
A very good companion for First Person Shooters, Flash Games, Media Players, for example.
Works great with a variety of gamepads, including (but not limited to) Xbox 360 and Ps3.
Mac OS X 10.6,
Mac OS X 10.7,
Mac OS X 10.8